This web page was produced as an assignment for Genetics 564, an undergraduate course at UW-Madison.
What is a protein interaction network?
A protein interaction network is a representation of all the different proteins that one protein might interact with. Using these networks, one can determine what are the likely functions of a protein of interest. The protein interaction network database String was used to find COL5A1's different protein interactions.
What does the COL5A1 gene product interaction network look like?
Analysis
It is known that the different types of collagen interact with one another while forming fibrils (1). Knowing this, it is expected that COL5A1's gene product would interact with a lot of other types of collagen. There were other interactions that further explained COL5A1's role in fibril synthesis. ITGA codes for Integrin, a protein found on the outside of cells that contains a domain that is used to bind to collagen. Next there was MMP2, which codes for a collagenase. This is used to dissolve collagen fibers. This makes sense as there should be something that can remove these fibrils if necessary. Finally there was THBS, which codes for thrombospondin-1. This is involved in angiogenesis. This also makes sense as blood vessels are made of connective tissues, something that is composed of collagen.
References
- Kadler KE, Holmes DF, Trotter JA, Chapman JA. Collagen fibril formation.Biochemical Journal. 1996;316(Pt 1):1-11.
Website Author: Logan Silber
Contact email: [email protected]
Page last updated: 5/15/2015
Course Homepage: www.genetics564.weebly.com
Contact email: [email protected]
Page last updated: 5/15/2015
Course Homepage: www.genetics564.weebly.com